When
it comes to the question of whether to use hormone replacement therapy
the answer is always one of personal choice.
The key to making
the appropriate decision is based on both the knowledge of what menopause
represents in terms of its potential impact on health, quality of life
and sexuality and an understanding how hormone replacement options differ
in their potential benefits and risks.
Without this knowledge,
a woman cannot effectively participate in her own healthcare decisions.
In essence, she becomes the passive recipient of her doctor’s
store of knowledge and individual bias.
Acquiring the necessary
information may be difficult for most women as the physician is the
source she usually turns to for information. Doctors may have only scant
knowledge of the menopausal process, its global nature, or the extent
of its potential impact on health and quality of life. In addition,
most physicians are not aware of what constitutes an optimum hormone
replacement regimen.
Menopause
101
A “natural
menopause” is characterized by cessation of the monthly menstrual
cycle and occurs because of an expected age-related failure of the ovaries
to continue to produce estradiol, the biologically-active form of estrogen.
Most often, this will occur between the ages of 48-52. It is the rise
in the estradiol level at puberty that is responsible for the physical
and mental metamorphosis from a young girl to an adult female. This
includes all the changes that that we characterize as “secondary
sexual characteristics.”
An early or “premature
menopause” is one that occurs prior to age 40 and can be the result
of genetic factors or autoimmune processes. An “induced menopause”
can be due to surgical removal of the ovaries with or without a hysterectomy,
by chemotherapy or radiation.
After menopause,
estradiol concentrations in the blood fall to their prepubertal level.
The aging process is accelerated as the hormonally-dependent tissues
that have relied on estradiol for their support begin to regress and
their ability to function optimally is compromised. Virtually every
organ system is affected including the vagina, bladder, brain, skin,
skeleton and cardiovascular.
Hormone
Deficient
Many women think
in terms of “going through menopause.” What they usually
mean is that they have stopped having symptoms such as hot flashes,
sweats and insomnia. However, unless a menopausal woman chooses to use
hormone replacement she will spend the remainder of her life in a hormone-deficient
state. The central issue for most menopausal women is whether to use
hormone replacement.
Menopause - assuming
it is a “natural menopause” - is normal. There is no “right
choice” for everyone. Whether a woman chooses to live in a hormone-deficient
state or use hormone replacement is a personal decision. In most cases,
menopausal symptoms such as hot flashes, sweats and insomnia will disappear
within 2 years. However, long-term consequences of estrogen deficiency
cannot be predicted on an individual basis, but many women on the surface
do not seem to be affected.
If a woman has experienced
a premature or induced menopause the effects are magnified. Those who
have had their ovaries removed are at greatest risk of osteoporosis,
cardiovascular disease and atrophic changes of the vagina, urinary system
and skin especially when this occurs prior to an expected natural menopause.
Women who choose
to use hormone replacement have a better quality of life according to
a recent pole conducted by The Gallup Organization. This is not meant
to imply that postmenopausal women who are not on hormone replacement
are incapable of a fulfilling life and sexual experience. They are capable
of both. We have all heard about “Aunt Sadie” who never
touched a hormone, or any other medication for that matter, yet lived
to age 94, remained “sharp as a tack,” had a sexually satisfied
boyfriend thirty years younger, drove a car every day and mowed her
own lawn. However, the point is that it is unlikely that anyone, regardless
of gender, can function optimally in a hormonally deficient state.
PANACEA
OR POISON?
Appropriate
Hormone Replacement Therapy known as HRT, remains a viable and important
health care option for postmenopausal women.
What
is OPTIMUM HORMONE REPLACEMENT?
In
this section, Dr N discusses optimal hormone replacement regimens.